A minor drug interaction exists between Advair Diskus and Spiriva. View detailed information regarding this drug interaction. Mechanism and Rationale Spiriva (tiotropium) is a long-acting anticholinergic (LAMA) that provides sustained bronchodilation through a different pathway than the beta-agonist in Advair. 1 Advair combines an inhaled corticosteroid (fluticasone) with a long-acting beta-agonist (salmeterol), addressing both inflammation and bronchodilation. 4 When Are Advair and Spiriva Prescribed Together? If you have moderate to severe persistent asthma and need a step up in treatment, your doctor may have you take both drugs. A phase IV clinical study of FDA data: drug interactions are found among 1,004 people who take Spiriva respimat (tiotropium bromide) and Advair hfa (fluticasone propionate; salmeterol xinafoate). Mit unserem Wechselwirkungs-Check prüfen Sie ganz einfach, ob sich Ihre Arzneimittel gegenseitig beeinflussen Yes: That is the correct dosing for both of these medications. If ever you have questions, contact (1st) your doctor, then the pharmacist. Do many of you here take both Advair and Spiriva each day. I had fought against Advair because the steroid effect also has an effect on my blood pressure and blood glucose levels. I was switched to Spiriva alone. Now, my new Pulmonologist tell me I will live longer if I take both each day… A dr. prescribed levofloxacin , 500, mg, i stopped taking after 5 days, that was two days ago, my kidneys are hurting both side i have copd i take spiriva or advair for that, and had a lung infection, he told me he would prescribe some strong meds. i ask A doctor has provided 1 answer A member asked: